HumanGenomeDating
Atlas of Variant Age
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Examples: LCT, MCM6, EDAR, ZEB1
Shared Ancestry Database
TGP
1000 Genomes Project
Populations: 26
Individuals: 2,535
Ancestry analyses:565,507,800
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SGDP
Simons Genome Diversity Project
Populations: 130
Individuals: 278
Ancestry analyses:6,800,992
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Genealogical Estimation of Variant Age (GEVA)

Inference of the ancestral origin of a genetic variant at a single locus

rs373272029
Alleles:
reference
T
ancestral
alternate
C
derived
Age estimated for the alternate allele, assuming that it was derived from the reference allele as the ancestral state.
How was the ancestral/derived state determined?Chromosome 2   position  109,579,376  (GRCh37) Explore rs373272029 on Ensembl!
Allele frequency in   SGDP ⇪
Sample 99.6%
0.4%
AFR 97.7%
2.3%
AMR 100.0%
0.0%
CAS 100.0%
0.0%
EAS 100.0%
0.0%
OCN 100.0%
0.0%
SAS 100.0%
0.0%
WEA 100.0%
0.0%
reference ← allele frequency → alternate
Select clock model
  Mutation clock
  Recombination clock
  Joint clock
Age estimation summary Recombination clock
Data source Estimated age of C allele # pairs = concordant + discordant Quality score
    Genomes in SGDP278.9 generations 94  =  1  +  930.946
Pairwise results table Recombination clock
Haplotype pair Pair type Data source Breakpoint positions Physical length (bp) Genetic Length (cM) α β Mean TMRCA (generations)
S_BantuHerero-2A + S_Biaka-1B Concordant SGDP 109,556,534 – 109,583,531 26,996.5 0.02320276 3 19.5622 3,067.1
S_Biaka-1B + S_Yoruba-2A Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_Biaka-1B + S_North_Ossetian-1A Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_Biaka-1B + S_Orcadian-2B Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_Biaka-1B + S_Palestinian-3A Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_BantuHerero-2A + B_Sardinian-3B Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_BantuHerero-2A + S_Sindhi-2A Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_Biaka-1B + S_Surui-2A Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_Biaka-1B + S_Mbuti-2B Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_Biaka-1B + S_Burmese-2A Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_Biaka-1B + S_Mbuti-3A Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_Biaka-1B + S_Biaka-2A Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_Biaka-1B + S_Tlingit-2A Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_Biaka-1B + S_BantuTswana-2B Discordant SGDP 109,032,031 – 109,579,402 547,371.5 0.19315706 3 155.5257 385.8
S_Biaka-1B + S_Tubalar-2A Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_Biaka-1B + B_Dinka-3A Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_Biaka-1B + S_Saharawi-2B Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_Biaka-1B + S_Mbuti-1B Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_BantuHerero-2A + S_BantuTswana-1B Discordant SGDP 108,954,234 – 109,579,402 625,168.0 0.29518349 3 237.1468 253.0
S_Biaka-1B + S_Gambian-1A Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_BantuHerero-2A + S_Basque-2B Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_Biaka-1B + S_Mozabite-2B Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_BantuHerero-2A + S_Mandenka-2B Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_Biaka-1B + S_BantuKenya-2A Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_Biaka-1B + S_Tuscan-1B Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_Biaka-1B + S_Mansi-2B Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_Biaka-1B + S_Saharawi-1B Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_Biaka-1B + S_Bengali-2B Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_Biaka-1B + S_Ju_hoan_North-1A Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_Biaka-1B + S_Somali-1A Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_Biaka-1B + B_Ju_hoan_North-4A Discordant SGDP 109,151,036 – 109,579,402 428,366.0 0.18385903 3 148.0872 405.2
S_Biaka-1B + S_Yadava-2A Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_Biaka-1B + S_Mende-1B Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_Biaka-1B + S_Irula-2B Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_Biaka-1B + S_Dinka-2B Discordant SGDP 108,984,664 – 109,579,402 594,738.5 0.20399134 3 164.1931 365.4
S_Biaka-1B + S_Brahmin-1A Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_Biaka-1B + S_Piapoco-2A Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_Biaka-1B + S_Kusunda-1B Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_BantuHerero-2A + S_Gambian-2A Discordant SGDP 108,954,234 – 109,579,402 625,168.0 0.29518349 3 237.1468 253.0
S_Biaka-1B + S_Luhya-2A Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_BantuHerero-2A + S_Saami-2A Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_Biaka-1B + S_Brahui-2A Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_BantuHerero-2A + S_Abkhasian-2B Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_Biaka-1B + S_Balochi-1B Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_BantuHerero-2A + S_Mandenka-1A Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_Biaka-1B + S_Brahui-1B Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_Biaka-1B + S_Mozabite-1A Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_Biaka-1B + S_Luo-2A Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_Biaka-1B + S_BedouinB-1B Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_Biaka-1B + S_Hazara-1A Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_Biaka-1B + S_Jordanian-2B Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_Biaka-1B + S_Sindhi-1B Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_Biaka-1B + S_Russian-1B Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_Biaka-1B + S_Punjabi-2B Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_Biaka-1B + S_Lezgin-2A Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_Biaka-1B + S_Punjabi-4B Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_Biaka-1B + S_Adygei-2B Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_Biaka-1B + S_Luhya-1B Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_Biaka-1B + B_Crete-1B Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_Biaka-1B + S_Bulgarian-2B Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_Biaka-1B + B_Mbuti-4B Discordant SGDP 109,558,177 – 109,581,776 23,599.5 0.01198719 3 10.5898 5,665.9
S_Biaka-1B + S_Saharawi-1A Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_Biaka-1B + B_Yoruba-3A Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_Biaka-1B + S_Estonian-1A Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_Biaka-1B + S_Esan-2B Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_Biaka-1B + S_Finnish-2A Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_Biaka-1B + S_Mende-2A Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_Biaka-1B + S_Finnish-3B Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_Biaka-1B + S_Khomani_San-1B Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_Biaka-1B + S_BantuKenya-1B Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_Biaka-1B + S_Surui-1B Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_Biaka-1B + S_French-1A Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_Biaka-1B + S_Piapoco-1B Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_Biaka-1B + S_Masai-2A Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_BantuHerero-2A + S_BantuTswana-1A Discordant SGDP 108,954,234 – 109,579,402 625,168.0 0.29518349 3 237.1468 253.0
S_Biaka-1B + S_Georgian-2B Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_BantuHerero-2A + S_Gambian-1B Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_Biaka-1B + S_Georgian-1B Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_BantuHerero-2A + S_Khonda_Dora-1A Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_Biaka-1B + S_Greek-1A Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_BantuHerero-2A + S_Finnish-2B Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_Biaka-1B + S_Hungarian-2B Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_BantuHerero-2A + S_French-1B Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_Biaka-1B + S_Hungarian-1A Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_BantuHerero-2A + S_Iranian-2A Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_Biaka-1B + S_Hungarian-1B Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_BantuHerero-2A + S_Yoruba-2A Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_Biaka-1B + S_Icelandic-1B Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_BantuHerero-2A + S_Saharawi-2A Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_Biaka-1B + S_Iranian-1A Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
S_BantuHerero-2A + S_Mandenka-2A Discordant SGDP 109,558,177 – 109,581,776 23,599.5 0.01198719 3 10.5898 5,665.9
S_Biaka-1B + S_Masai-1A Discordant SGDP 108,954,234 – 109,579,402 625,168.0 0.29518349 3 237.1468 253.0
S_BantuHerero-2A + S_Mende-2A Discordant SGDP 108,954,234 – 109,579,402 625,168.0 0.29518349 3 237.1468 253.0
S_Biaka-1B + S_Druze-1B Discordant SGDP 109,579,352 – 109,579,402 50.0 0.00003123 3 1.0250 58,537.3
View as figure
Data shown in this table can be downloaded from this page.
α Shape parameter of the Gamma distribution, calculated from the number of pairwise differences along the sequence of the inferred shared haplotype segment (mutation clock), or the breakpoints detected (recombination clock), or both (joint clock); plus the parameter of the coalescent prior distribution (equal to 1 by default).
β Rate parameter of the Gamma distribution, calculated from the physical length of the inferred shared haplotype segment and the mutation rate (mutation clock), or the genetic length given the variable recombination rate (recombination clock), or both (joint clock); plus the parameter of the coalescent prior distribution (equal to 1 by default).
Mean TMRCA Calculated as the mean of the Gamma distribution with parameters α and β, multiplied by 2 x Ne, where Ne = 10,000 by default.
 

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