Populations:	`26`
Individuals:	`2,535`
Ancestry analyses:	`565,507,800`

Populations:	`130`
Individuals:	`278`
Ancestry analyses:	`6,800,992`

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Genealogical Estimation of Variant Age (GEVA)

Inference of the ancestral origin of a genetic variant at a single locus

rs535456766

Alleles:

reference

ancestral

alternate

derived

Age estimated for the alternate allele, assuming that it was derived from the reference allele as the ancestral state.

How was the ancestral/derived state determined?Chromosome 2 position 136,531,531 (GRCh37)

Explore rs535456766 on Ensembl!

ShowHide allele frequencies

Allele frequency in SGDP ⇪

Sample	`98.6%`		`1.4%`
`AFR`	`90.9%`		`9.1%`
`AMR`	`100.0%`		`0.0%`
`CAS`	`100.0%`		`0.0%`
`EAS`	`100.0%`		`0.0%`
`OCN`	`100.0%`		`0.0%`
`SAS`	`100.0%`		`0.0%`
`WEA`	`100.0%`		`0.0%`
	reference	← allele frequency →	alternate

Select clock model

Mutation clock

Recombination clock

Joint clock

Age estimation summary Mutation clock

Data source	Estimated age of `C` allele	# pairs = concordant + discordant	Quality score
Genomes in SGDP	`8,399.6` generations	`115` = `22` + `93`	`0.989`

Pairwise results table Mutation clock

Haplotype pair	Pair type	Data source	Breakpoint positions	Physical length (bp)	Genetic Length (cM)	α	β	Mean TMRCA (generations)
S_Ju_hoan_North-1A + B_Ju_hoan_North-4A	Concordant	SGDP	`136,401,078` – `137,093,720`	`692,641.5`	`0.63258900`	47	333.4679	2,818.9
S_Ju_hoan_North-2B + S_Khomani_San-2B	Concordant	SGDP	`136,482,918` – `136,559,711`	`76,792.5`	`0.01436618`	10	37.8604	5,282.6
S_Ju_hoan_North-2B + S_Khomani_San-1A	Concordant	SGDP	`136,411,978` – `136,801,475`	`389,497.5`	`0.12086568`	33	187.9588	3,511.4
S_Ju_hoan_North-2B + S_Ju_hoan_North-1A	Concordant	SGDP	`136,406,898` – `137,034,384`	`627,485.5`	`0.40473764`	30	302.1930	1,985.5
S_Ju_hoan_North-2B + B_Ju_hoan_North-4A	Concordant	SGDP	`136,341,972` – `137,058,509`	`716,537.0`	`0.56883420`	39	344.9378	2,261.3
S_Ju_hoan_North-1A + S_Khomani_San-1A	Concordant	SGDP	`135,729,071` – `136,801,475`	`1,072,404.5`	`0.29129866`	171	515.7542	6,631.1
S_Khomani_San-2A + S_Khomani_San-1A	Concordant	SGDP	`136,482,918` – `136,559,711`	`76,792.5`	`0.01436618`	12	37.8604	6,339.1
S_Ju_hoan_North-3A + S_Ju_hoan_North-1A	Concordant	SGDP	`136,399,121` – `136,644,413`	`245,292.0`	`0.04213799`	16	118.7402	2,695.0
S_Ju_hoan_North-3A + B_Ju_hoan_North-4A	Concordant	SGDP	`135,439,018` – `136,644,413`	`1,205,395.0`	`0.34527206`	101	579.5896	3,485.2
S_Mbuti-1A + S_Khomani_San-1A	Concordant	SGDP	`136,489,176` – `136,588,252`	`99,076.0`	`0.01619202`	12	48.5565	4,942.7
S_Ju_hoan_North-3A + S_Ju_hoan_North-2B	Concordant	SGDP	`136,406,898` – `136,644,413`	`237,515.0`	`0.04190494`	9	115.0072	1,565.1
S_Mbuti-1A + S_Khomani_San-2A	Concordant	SGDP	`136,491,330` – `136,559,711`	`68,381.0`	`0.01247340`	9	33.8229	5,321.8
S_Mbuti-1A + B_Ju_hoan_North-4A	Concordant	SGDP	`136,489,176` – `136,588,252`	`99,076.0`	`0.01619202`	7	48.5565	2,883.2
S_Mbuti-1A + S_Ju_hoan_North-1A	Concordant	SGDP	`136,489,176` – `136,588,252`	`99,076.0`	`0.01619202`	11	48.5565	4,530.8
S_Ju_hoan_North-1A + S_Khomani_San-2A	Concordant	SGDP	`136,482,918` – `136,559,711`	`76,792.5`	`0.01436618`	13	37.8604	6,867.3
S_Ju_hoan_North-3A + S_Khomani_San-2A	Concordant	SGDP	`136,482,918` – `136,559,711`	`76,792.5`	`0.01436618`	12	37.8604	6,339.1
S_Ju_hoan_North-1A + S_Khomani_San-2B	Concordant	SGDP	`136,482,918` – `136,559,711`	`76,792.5`	`0.01436618`	11	37.8604	5,810.8
S_Ju_hoan_North-3A + S_Khomani_San-1A	Concordant	SGDP	`136,080,221` – `136,644,413`	`564,192.5`	`0.06056790`	111	271.8124	8,167.4
S_Khomani_San-2A + B_Ju_hoan_North-4A	Concordant	SGDP	`136,482,918` – `136,559,711`	`76,792.5`	`0.01436618`	11	37.8604	5,810.8
S_Khomani_San-1A + B_Ju_hoan_North-4A	Concordant	SGDP	`136,080,221` – `136,786,842`	`706,621.0`	`0.09231650`	132	340.1781	7,760.6
S_Mbuti-1A + S_Ju_hoan_North-3A	Concordant	SGDP	`136,489,176` – `136,588,252`	`99,076.0`	`0.01619202`	7	48.5565	2,883.2
S_Mbuti-1A + S_Ju_hoan_North-2B	Concordant	SGDP	`136,489,176` – `136,588,252`	`99,076.0`	`0.01619202`	8	48.5565	3,295.1
S_Mbuti-1A + S_Bergamo-2A	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + S_Samaritan-1A	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + S_Icelandic-1B	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + S_Greek-2B	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + S_Yemenite_Jew-1A	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + S_North_Ossetian-1B	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + S_Orcadian-2B	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + S_Finnish-3A	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Khomani_San-2A + B_Sardinian-3A	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Khomani_San-2B + S_Eskimo_Naukan-2B	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Khomani_San-2A + S_Punjabi-3A	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Ju_hoan_North-1A + S_Czech-2B	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + S_Saharawi-2B	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + S_Tuscan-2A	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + S_BantuKenya-1B	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + S_Norwegian-1A	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + S_Saami-2A	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + S_Lezgin-2A	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + S_Basque-1B	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + S_Adygei-2A	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + S_Spanish-2B	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + S_Turkish-1B	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + S_Mozabite-1B	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + B_French-3B	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + S_Mixe-3A	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + S_Karitiana-1A	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + S_Mixtec-1B	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Khomani_San-2A + S_Mixe-2A	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + S_Mongola-2A	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Khomani_San-2A + S_Hungarian-2A	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + S_Tlingit-1B	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Khomani_San-2B + S_Eskimo_Chaplin-1A	Discordant	SGDP	`136,531,527` – `136,762,052`	`230,524.5`	`0.02921296`	35	111.6518	6,269.5
S_Mbuti-1A + S_Aleut-2A	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Khomani_San-2B + B_Karitiana-3B	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + S_Dai-3B	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + S_Finnish-1A	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + S_Uygur-1B	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + S_Finnish-3B	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + S_Xibo-1A	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + S_Saami-1A	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + S_Yi-2A	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + S_French-2A	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + S_Xibo-2A	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + S_Georgian-2A	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + S_Dai-1A	Discordant	SGDP	`135,793,417` – `136,531,556`	`738,138.5`	`0.04865630`	165	355.3065	9,287.8
S_Mbuti-1A + S_Icelandic-1A	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + S_Thai-2B	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + S_Iranian-1B	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + S_Kinh-2A	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + S_Druze-1B	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + S_Maori-1B	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + S_Bergamo-2B	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + S_Chukchi-1B	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + S_Jordanian-3B	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + S_Mozabite-2B	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + S_Orcadian-1B	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + S_Mansi-2A	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + S_Polish-1B	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + S_Brahmin-2B	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + S_Lezgin-1B	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + S_Balochi-1B	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + S_Adygei-1B	Discordant	SGDP	`135,793,417` – `136,531,556`	`738,138.5`	`0.04865630`	169	355.3065	9,512.9
S_Mbuti-1A + S_Brahui-1A	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + S_Spanish-1B	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + S_Brahui-1B	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + S_Tajik-2B	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + S_Makrani-2B	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + S_Yemenite_Jew-2B	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + S_Pathan-2A	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + B_Crete-2B	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + S_Burusho-2A	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + B_Mixe-1A	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + S_Hazara-1A	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + S_Surui-2B	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + S_Sindhi-2A	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Ju_hoan_North-1A + S_Mongola-2A	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + S_Punjabi-2A	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Ju_hoan_North-1A + S_Kyrgyz-2A	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + S_Punjabi-4A	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Khomani_San-2A + S_Itelman-1B	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + S_Bulgarian-1A	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Khomani_San-2A + S_Bulgarian-2B	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + S_Atayal-1A	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Khomani_San-2A + S_Spanish-1B	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + S_English-1A	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Khomani_San-2B + S_Eskimo_Sireniki-1B	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + S_English-2A	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Khomani_San-2B + S_Oroqen-1B	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + S_Estonian-2A	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Khomani_San-2B + S_Tajik-2B	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + S_Estonian-1A	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Khomani_San-2B + S_Chane-1B	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2
S_Mbuti-1A + S_Estonian-1B	Discordant	SGDP	`136,531,527` – `136,531,556`	`28.5`	`0.00000236`	2	1.0137	39,460.2

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Data shown in this table can be downloaded from this page.

Mean TMRCA	Calculated as the mean of the Gamma distribution with parameters α and β, multiplied by 2 x Ne, where Ne = 10,000 by default.
α	Shape parameter of the Gamma distribution, calculated from the number of pairwise differences along the sequence of the inferred shared haplotype segment (mutation clock), or the breakpoints detected (recombination clock), or both (joint clock); plus the parameter of the coalescent prior distribution (equal to 1 by default).
β	Rate parameter of the Gamma distribution, calculated from the physical length of the inferred shared haplotype segment and the mutation rate (mutation clock), or the genetic length given the variable recombination rate (recombination clock), or both (joint clock); plus the parameter of the coalescent prior distribution (equal to 1 by default).